Preacher is a comic book series created by writer Garth Ennis and artist Steve Dillon, published by the American comic book label Vertigo (an imprint of DC Comics), with painted covers by Glenn Fabry.
The series consists of 75 issues in total—66 regular, monthly issues, five one-shot specials and a four-issue Preacher: Saint of Killers limited series. The entire run has been collected in nine trade paperback editions. The final monthly issue, number 66, was published in July 2000.
Preacher tells the story of Jesse Custer, a preacher in the small Texas town of Annville. Custer was accidentally possessed by the supernatural creature named Genesis in an incident which killed his entire congregation and flattened his church.
Genesis, the product of the unauthorized, unnatural coupling of an angel and a demon, is an infant with no sense of individual will. However, as it is composed of both pure goodness and pure evil, it might have enough power to rival that of God Himself. In other words, Jesse Custer, bonded to Genesis, may have become the most powerful being in the whole of living existence.
Custer, driven by a strong sense of right and wrong, goes on a journey across the United States attempting to (literally) find God, who abandoned Heaven the moment Genesis was born. He also begins to discover the truth about his new powers. They allow him, when he wills it, to command the obedience of those who hear and comprehend his words. He is joined by his old girlfriend Tulip O'Hare, as well as a hard-drinking Irish vampire named Cassidy.
During the course of their journeys, the three encounter enemies and obstacles both sacred and profane, including: the Saint of Killers, an invincible, quick-drawing, perfect-aiming, come-lately Angel of Death answering only to "He who sits on the throne"; a disfigured suicide attempt survivor turned rock-star named Arseface; a serial-killer called the 'Reaver-Cleaver'; The Grail, a secret organization controlling the governments of the world and protecting the bloodline of Jesus; Herr Starr, ostensible Allfather of the Grail, a megalomaniac with a penchant for prostitutes, who wishes to use Custer for his own ends; several fallen angels; and Jesse's own redneck 'family' — particularly his nasty Cajun grandmother, her mighty bodyguard Jody, and the 'animal-loving' T.C.